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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 10 Documents

Search results for , issue "Vol 16 No 4, 2005" : 10 Documents clear

Quantitative structure-activity relationship of curcumin and its derivatives as μ-class of GST inhibitors Enade Perdana Istyastono; Sudibyo Martono
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The Quantitative Structure-Activity Relationship (QSAR) study has been performed on curcumin and its derivatives as μ-class glutathione Stransferase inhibitors using atomic net charges as the predictors. The charges were resulted by semiempirical AM1 quantum-chemical calculations using the computational chemistry approach. The inhibition activity was expressed as the concentration that gave 50% inhibition of μ-class GST activity (IC50). The selection of the best QSAR equation models was determined by multiple linear regression analysis. Curcumin and its derivatives were reported as selective μ-class GST inhibitors. The enzyme plays an important role in the process of inflammation and the effectivity of anti lung-cancer compounds. μ-Class GST inhibitors could enhance the effectivity of anti lung-cancer compounds.The result showed that the best QSAR equation model of curcumin and its derivatives as μ-class GST inhibitors was described by.: log (1/IC50) = (-454.686) + (314.235)qC2 + (1593.499)qC3 + (452.563)qC4 + (1057.194)qC5 + (-1.756)qBenzene’ The equation was significant at 95% level with statistical parameters : n = 10, m = 5, F/FTabel = 3.335, R2 = 0.963, SE = 0.150, and PRESS = 0.559.Key words : QSAR analysis, curcumin, μ-class glutathione S-transferase, atomic net charge.

Synthesis of potassium pentagamavunonat-0 using potassium hydroxyde and solvent tertrahydrofuranethanol Supardjan Amir Margono; Ester Yani Verawati
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Pentagamavunon-0 (PGV-0) (2,5-bis(4’-hydroxy-3’-methoxy benzy-lidene) cyclopentanone) is a curcumin analogue. To improve its bioavailability it has been succesfully synthesized the Na-salt of this compound. However, sodium may disturb the electrolyte liquid-balance in the body which in turn hypertension. Therefore, the synthesis of potassium pentagamavunonat-0 is attempted. Synthesis has been done using potassium hydroxide as a potassium source, in tetrahydrofuran-ethanol solvent, with molar variations. The result is dipotassium pentagamavunonate-0 (elucidated with IR, 1H-NMR, 13C-NMR and MS spectra), which is more soluble in water and has better stability at high pHs. Molar variations did not show correlation with its yield. The yields are more than 100 %, may be caused by water crystals that contaminate the compound. Key words : pentagamavunon-0, dikalium pentagamavunonat-0, synthesis

Characterization of 99mTc-ciprofloxacin radiopharmaceuticals as the infection imaging Nurlaila Z; T. Hasan Basry; Rukmini Iljas; Mimin R. Suminar
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Technetium-99m-ciprofloxacin (99mTc-ciprofloxacin) is used in nuclear medicine for infection diagnoses by imaging method. Since a succesful diagnose is depend on its radiopharmaceutical characters, the several physicochemical and biological characters should be investigated in order to have the expectation diagnose. The radiochemical purity was determined with ascending paper chromatography (Whatman 3MM) using 50 % of acetonitril solution as the solvents. The lipophilicity =(P) of 99mTcciprofloxacin was obtained by determination of octanol-water partition and the plasma binding protein was in-vitro investigated with precipitation method using 5% of trichloro acetic acid solution. The biological activity of antibiotic and microbiological uptake was observed in-vitro using Staphylococcus aureus (S. aureus) and Escherichia coli (E.coli). From the experiment, it was obtained that 99mTc-ciprofloxacin has 98.04 ± 0.51 % of radiochemical purity, the lipophilicity (P) = 0.088 ± 0.003, the human plasma binding protein of 64.20 ± 1.74%. The biological activity of 99mTcciprofloxacin was indentic with ciprofloxacin as the starting material and the maximum uptake by S. aureus and E.coli was 97.30 ± 1.01% and 96.03 ± 2.10%, at one hour incubation, respectively. The stability determination showed that 99mTc-ciprofloxacin was still able to be used until two hours after labelling with radiochemical purity of 97.55 ± 0.24%.Key words :radiopharmaceutical, technetium-99m, ciprofloxacin, in, characterization.

The acute toxicity of isolates from n-hexane and ethanolic fraction of Dendrophthoe pentandra (L.) Miq. which have immunostimulatory activity Katrin .; Andreanus A. Soemardji; Asep Gana Soeganda; Iwang Soediro
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The acute toxiciy of two isolates from n-hexane fraction and ethanolic fractions of Dendrophthoe pentandra ( L) Miq. leaves have been investigated. Isolate HD54 (ß-sitosterol) Isolat HD54 (ß-sitosterol) isolated from nhexane fraction and ED44 (quercitrine) from ethanolic fraction, which these two fraction have immunostimulatory activity. The acute toxicity test of isolates were investigated on mice after giving a single dose of samples by observing their influences on behavioral responses (pharmacological profile), the development of body weight and mortality each day for 14 days. The observation vital organ have been done on fifteeth day. The results of acute toxicity test after giving the two isolates to males and females mice showed that until a dose of 2000 mg/kg body weight was no animal died and significant toxic effect. Therefore LD50 of the two isolates on mice were higher than 2000 mg/kg body weight. Key words : acute toxicity, immunostimulant, Dendrophthoe pentandra (L.) Miq., LD50 .

Single dose trypanocide surveillance of diminazene aceturate on mice infected by trypanosoma Lazuardi, Mochamad
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Diminazene aceturate is one of a limited number compounds currently market for treatment infection cases of infection blood eucaryot parasits llike a Leishmania, and Trypanosoma The research design of this research was post test only control groups design for founding single therapeutics dose of the eukariyot parasite blood. The serial range dose of this research was used at 1,5 to 4 mg/kg bw by intraperitoneal administreted to infected mice (Mus musculus albinus) of the Trypanosoma evansi Bangkalan isolates. The result of this research showed the minimum single therapeutics dose at 3,5 mg/kg bw (p

Formulation of repellant gel of vetiver oil : Composition of carbopol 3% w/v – propilenglicol optimization Sri Hartati Yuliani
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

3% w/v solution and propilenglikol,and to observe the dominant effect among Carbopol 3% w/v, propilenglikol and their interaction in determining the physical properties of vetiver oil repellant gel. Moreover the repellant potency against female Aedes albopictus and iritation skin test on rabbit were also confirmed.Firstly, vetiver oil was collected from dried root of Vetivera zizoioides (L) Nogh by water steam destilation. The obtained oil then was gelled by the aid of Carbopol 3% w/v solution – propilenglikol at various compositions. Factorial design method was employed to create the optimum composition of Carbopol 3% w/v solution – propilenglikol and was used to determined the effect of Carbopol 3% w/v solution – propilenglikol and their interaction on the gel characteristics.The result showed that the effect of Carbopol 3% w/v solution was the dominant factor in the viscosity and repellant potency. While the effect of propilenglikol was the dominant factor in alteration of gel viscosity. The interaction between Carbopol 3% w/v solution and propilenglikol was dominant factor in spreadability. The optimum composition was created in superimposed countour plot. Irritation skin test on rabbit confirmed that all evaluated formulas were non irritatingKey words: formulation, repellant gel, vetiver oil

Diosgenin production by immobilized cell Soegihardjo, C.J.; ., Koensoemardiyah
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

In the last two decade, secondary metabolite production by plant tissue culture in several countries by plant tissue cultures were done by plant suspension culture method, in volumes until several thousand litres. There are many problems occur in the production by cells suspension culture. Some problems could be overcome by choosing suitable media, other could be solving by immobilized cells system. Immobilized cells system is promising method because it has some advantages. The aim of this research is to produce diosgenin from amobilized cells of Costus speciosus Smith. From this result we hope to know about the possibility of using immobilized cells system as alternative method for producing diosgenin. The main substance of this research is the mature seeds of C. speciosus (fam. Zingiberaceae) grown in RT-0 semisolid medium. The seedlings become explant for initiating calli by growing in RT 1 semisolid medium. After some passages of subculturing the calli, initiation of cell suspension culture was carried out by growing friable calli on RT-0,1 liquid medium. After some passages of subculturing cell suspesion culture, the biomass were collected and trapped in calcium alginate beads. The type of bioreactor used was shaking-flask. The immobilized cells were treated in RT liquid medium added with 0.1 ppm 2,4-D (RTA), second group in RTA added with 0.2% yeast extract (RTB), and the third group in RTA added with 0.2% yeast extract and 0.05% cholesterol. From this investigation can be concluded that diosgenin production in immobilized cell system treated with elicitor and precursor was increased four to ten times as great as its production without any addition for fine cells and for coarse cells about eight and three times fold. Key words: Costus speciosus cells, diosgenin production, immobilized cells, elicitation, precursor, spectro-densitometri.

Identification of cubebin and epicubebin isolated from Piper cubeba L.f fruits with two D-NMR spectroscopy Wahyono .; S. Wahyuono; A. Mursyidi; H. Timmerman; R. Verpoorte; L. Hakim
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

One of the isolated active compound of the tracheospasmolytic from kemukus fruits (Piper cubeba L.f) is cubebin. The problem occurred when cubebin (C20H20O6) mixed with its epimer because of the difficultly to identify the structure by 1D-NMR spectroscopy. Structure identification then was conducted by 2D-NMR spectroscopy, so the structure of cubebin and epicubebin can be clear identified. Key words : Cubebin, epicubebin, identification, 2D-NMR

Isolation and structure elucidation of main compound originated from sponge Axynissa aplysinoides Sumaryono, Wahono; Wibowo, Agung Eru; ., Chaidir
INDONESIAN JOURNAL OF PHARMACY Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Isolation of the main compound of sponge Axynissa aplysinoides collected from Lombok seawater, has been conducted. Methanol extract of dried sponge was fractionated into nonpolar, semipolar and polar fractions using hexane, ethyl acetate and buthanol. Identification and final purification of the main compound was done using column chromatography and high performance liquid chromatography (HPLC). Structure elucidation of the main compound was performed using mass spectrometry (EIMS), 1H- and 13C-NMR spectroscopies. The main compound was identified as (E)-(4-hydroxystyryl) trimethylammonium.Key words : isolation, structure elucidation, Axynissa aplysinoides

Isolation of anticancer compound of Artemisia cina hairy root and its inhibition activity on cervix cancer cells. ., Aryanti; Ermayanti, Tri Muji; Mariska, Ika; Bintang, Maria
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research of isolation of anticancer agent of A.cina hairy roots and its inhibition activity on cervix cancer cells have been conducted. Hairy roots transformed by Agrobacterium rhizogenes strains A4 and ATCC-15834 were then extracted by n-hexane and separated by column chromatography with variation of n-hexane/ethyl acetate as eluent. All samples include hexane extract and result of column chromatography tested to cervix HeLa Ohio cells with concentration of 50 μg/ml for hexane extract and 10 μg/ml for column chromatography respectively. The most active fraction was then tested by the concentration of 1 to 5 μg/ml. Confirmation of transformed root of A.cina was conducted by PCR analysis. The result of experiment shown that hexane extract of hairy root, normal root ( in vitro ), leaves of plant from green house as a control gave the inhibition value were about 84 %. The most active fraction from column chromatography was fraction E with IC50 at the concentration of 1 μg/ml and inhibition value was 95 %, the identification compound of this fraction was terpenoid group. The confirmation result showed that TL-DNA was transferred by 780 kb.Key words : anticancer, hairy root, Artemisia cina.

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